Primary metabolites from overproducing microbial system using sustainable substrates.,Biotechnology and Applied Biochemistry

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Primary metabolites from overproducing microbial system using sustainable substrates.
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-04-15 , DOI: 10.1002/bab.1927
Rajesh K Srivastava ₁ , Nasim Akhtar ₁ , Malkhey Verma ₂ , Sarat Babu Imandi ₁

Affiliation

Primary (or secondary) metabolites are produced by animals, plants, or microbial cell systems either intracellularly or extracellularly. Production capabilities of microbial cell systems for many types of primary metabolites have been exploited at a commercial scale. But the high production cost of metabolites is a big challenge for most of the bioprocess industries and commercial production needs to be achieved. This issue can be solved to some extent by screening and developing the engineered microbial systems via reconstruction of the genome‐scale metabolic model. The predicted genetic modification is applied for an increased flux in biosynthesis pathways toward the desired product. Wherein the resulting microbial strain is capable of converting a large amount of carbon substrate to the expected product with minimum by‐product formation in the optimal operating conditions. Metabolic engineering efforts have also resulted in significant improvement of metabolite yields, depending on the nature of the products, microbial cell factory modification, and the types of substrate used. The objective of this review is to comprehend the state of art for the production of various primary metabolites by microbial strains system, focusing on the selection of efficient strain and genetic or pathway modifications, applied during strain engineering.

中文翻译：

使用可持续的底物，来自过量生产的微生物系统的主要代谢物。

一级（或二级）代谢产物是由动物，植物或微生物细胞系统在细胞内或细胞外产生的。微生物细胞系统对许多类型的主要代谢物的生产能力已在商业规模上得到开发。但是，对于大多数生物加工行业而言，代谢产物的高昂生产成本是一个巨大的挑战，需要实现商业化生产。通过重建基因组规模的代谢模型，筛选和开发工程微生物系统，可以在某种程度上解决这个问题。预测的遗传修饰可用于增加生物合成途径中通向所需产品的通量。其中所产生的微生物菌株能够在最佳操作条件下以最少的副产物形成量将大量碳底物转化为预期的产物。代谢工程的努力还导致代谢产物产率的显着提高，这取决于产品的性质，微生物细胞工厂的改造以及所用底物的类型。这篇综述的目的是了解通过微生物菌株系统生产各种主要代谢产物的技术水平，重点是在菌株工程中应用有效菌株的选择以及遗传或途径修饰。微生物细胞的工厂改造，以及所用底物的类型。这篇综述的目的是了解通过微生物菌株系统生产各种主要代谢产物的技术水平，重点是在菌株工程中应用有效菌株的选择以及遗传或途径修饰。微生物细胞的工厂改造，以及所用底物的类型。这篇综述的目的是了解通过微生物菌株系统生产各种主要代谢产物的技术水平，重点是在菌株工程中应用有效菌株的选择以及遗传或途径修饰。

更新日期：2020-04-15

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