Objective: The interactions between yeast and streptococci species that lead to dental decay and gingivitis are poorly understood. Our study describes these associations among a cohort of 101 post-partum women enrolled in the Center for Oral Health Research in Appalachia, 2012-2013. Methods: All eligible women without dental caries were included (n = 21) and the remainder were randomly sampled to represent the total number of decayed, missing, and filled teeth (DMFT) at enrollment. We used amplicon sequencing and qPCR of saliva from 2, 6, 12 and 24 visits to determine microbiome composition. Results: Active decay and generalized gingivitis were strongly predictive of each other. Using adjusted marginal models, Candida albicans and Streptococcus mutans combined were associated with active decay (OR = 3.13; 95% CI 1.26, 7.75). However, C. albicans alone (OR = 2.33; 95% CI: 0.81, 6.75) was associated with generalized gingivitis, but S. mutans alone was not (OR = 0.55; 95% CI: 0.21, 1.44). Models including microbiome community state types (CSTs) showed CSTs positively associated with active decay were negatively associated with generalized gingivitis. Discussion: C. albicans is associated with active decay and generalized gingivitis, but whether one or both are present depends on the structure of the co-existing microbial community.

中文翻译：

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产后酵母菌，链球菌，龋齿和牙龈炎的同时出现：一项纵向研究的结果。

目的：酵母与链球菌之间导致牙齿腐烂和牙龈炎的相互作用了解甚少。我们的研究描述了2012-2013年阿巴拉契亚州口腔健康研究中心招募的101名产后妇女队列中的这些关联。方法：纳入所有无龋齿的合格妇女（n = 21），随机抽取剩余的妇女代表入选时龋齿，缺失和充实牙齿（DMFT）的总数。我们使用了2、6、12和24次访问的唾液的扩增子测序和qPCR来确定微生物组的组成。结果：活动性衰老和泛发性牙龈炎相互之间具有强烈的相互关系。使用调整后的边际模型，白色念珠菌和变形链球菌的结合与活动衰减相关（OR = 3.13； 95％CI 1.26，7.75）。但是，C。单独的白色念珠菌（OR = 2.33； 95％CI：0.81、6.75）与广义牙龈炎相关，而单独的变形链球菌则不相关（OR = 0.55； 95％CI：0.21、1.44）。包括微生物组群落状态类型（CST）在内的模型显示，与活动性衰变呈正相关的CST与广义牙龈炎呈负相关。讨论：白色念珠菌与活动性腐烂和泛发性牙龈炎有关，但是否存在一种或两种细菌则取决于共同存在的微生物群落的结构。