Interactions between the immune system and the pancreas are pivotal in understanding how and why β cells' damage causes problems with pancreas functioning. Pancreatic islets are crucial in maintaining glucose homeostasis in organs, tissue and cells. Autoimmune aggression towards pancreatic islets, mainly β cells, leads to type 1 diabetes-one of the most prevalent autoimmune disease in the world, being a worldwide risk to health of many people. In this review, we highlight the role of immune cells and its influence in the development of autoimmunity in Langerhans islets. Moreover, we discuss the impact of the immunological factors on future understanding possible recurrence of autoimmunity on 3D-bioprinted bionic pancreas.

中文翻译：

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免疫系统细胞与胰腺之间的串扰。在3D生物打印过程中使用的干细胞转化，作为1型糖尿病的个性化治疗方法。

免疫系统与胰腺之间的相互作用对于理解β细胞的损伤如何以及为什么引起胰腺功能问题至关重要。胰岛对于维持器官，组织和细胞中的葡萄糖稳态至关重要。对胰岛（主要是β细胞）的自身免疫攻击会导致1型糖尿病，这是世界上最普遍的自身免疫疾病之一，对全世界许多人的健康都是一种危险。在这篇综述中，我们着重介绍了免疫细胞的作用及其在朗格汉斯胰岛自身免疫发展中的影响。此外，我们讨论了免疫因素对未来了解3D生物打印仿生胰腺自身免疫可能复发的影响。