The impact of the extraction technologies on product yield and analytical profile is relevant. This review is aiming to discuss recent experiences of successes and failures in non-conventional extraction scaling-up, to better understand the challenges and designing of existing and new techniques. Understanding the crucial extraction factors at laboratory and pilot scale is of paramount value for the engineering work of scaling-up. Besides, a careful analysis and modelling of heat and mass transfer and energy consumption, the design of industrial extraction plants driven by economic and environmental factors, are well covered in the present review. Current trend strongly favors scaling-up of green approaches that consumes less organic solvent(s), involves minimal operational steps, provides high throughput capability and assures highest yield at lower costs. Current and future challenges in scaling-up extraction of bioactive compounds require a parallel development of suitable analytical methods to monitor the process and ensure high yield and quality.

萃取技术对产品收率和分析曲线的影响是相关的。这篇综述的目的是讨论非常规提取技术成功与失败的最新经验，以更好地理解现有技术和新技术的挑战和设计。了解实验室和中试规模的关键提取因子对于扩大规模的工程工作至关重要。此外，本篇综述很好地涵盖了对传热和传质以及能源消耗的仔细分析和建模，以及受经济和环境因素驱动的工业提取厂的设计。当前的趋势强烈支持扩大绿色方法的使用，因为绿色方法消耗的有机溶剂更少，操作步骤最少，提供高吞吐能力，并以较低的成本确保最高的产量。扩大生物活性化合物提取的当前和未来挑战要求并行开发合适的分析方法来监测过程并确保高产量和高质量。