The elaborate control of biogenesis and turnover is essential for circular RNAs (circRNAs) to exert their functions properly in eukaryotic cells, whereas how circRNAs are degraded remains unclear. A recent study by Fischer et al. reveals a novel structure-mediated circRNA decay that selectively degrades highly structured RNAs by UPF1 and G3BP1.

中文翻译：

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CircRNAs的结构介导降解。

对于环RNA（circRNA）在真核细胞中正确发挥其功能，至关重要的是对生物发生和周转的精细控制，但是尚不清楚circRNA如何被降解。Fischer等人的最新研究。揭示了一种新型的结构介导的circRNA衰变，可通过UPF1和G3BP1选择性降解高度结构化的RNA。