Maintenance of mitochondrial function and integrity is critical for normal cell survival, particularly in non-dividing cells with a high-energy demand such as cardiomyocytes. Well-coordinated quality control mechanisms in cardiomyocytes, involving mitochondrial biogenesis, mitochondrial dynamics-fission and fusion, and mitophagy, act to protect against mitochondrial dysfunction. Mitochondrial fission, which requires dynamin-related protein 1 (Drp1), is essential for segregation of damaged mitochondria for degradation. Alterations in this process have been linked to cardiomyocyte apoptosis and cardiomyopathy. In this review, we discuss the role of Drp1 in mitophagy and apoptosis in the context of cardiac pathology, including myocardial ischemia and heart failure.

中文翻译：

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Drp1 在心脏线粒体自噬和细胞死亡中的作用。

维持线粒体功能和完整性对​​于正常细胞存活至关重要，尤其是在具有高能量需求的非分裂细胞中，例如心肌细胞。心肌细胞中协调良好的质量控制机制，包括线粒体生物发生、线粒体动力学-裂变和融合以及线粒体自噬，可以防止线粒体功能障碍。线粒体裂变需要动力蛋白相关蛋白 1 (Drp1)，对于分离受损线粒体进行降解至关重要。这一过程的改变与心肌细胞凋亡和心肌病有关。在这篇综述中，我们讨论了 Drp1 在心脏病理学背景下在线粒体自噬和细胞凋亡中的作用，包括心肌缺血和心力衰竭。