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Bisabolane sesquiterpenes and α-pyrone derivative from endophytic fungus Zopfiella sp
Phytochemistry Letters ( IF 1.3 ) Pub Date : 2020-04-15 , DOI: 10.1016/j.phytol.2020.03.008
Li-Tang Sun , Yao Chen , Hui-Xiang Yang , Zheng-Hui Li , Ji-Kai Liu , Guo-Kai Wang , Tao Feng

Three undescribed bisabolane sesquiterpenoids, zopfiellins A–C (13), and one new α-pyrone derivative, zofiellone (4), have been isolated from cultures of the endophytic fungus Zopfiella sp. Compound 2 is a rare trinor-bisabolane sesquiterpenoid and 3 has an unusual aromatic core. Compounds 3 and 4 possess mild cytotoxicities against three human cancer cell lines with a range of IC50 values from 12.3–27.3 μM.



中文翻译:

内生真菌Zopfiella sp。的倍沙硼烷倍半萜和α-吡喃酮衍生物

三个未描述的倍半萜bisabolane,zopfiellins A-C(1 - 3),以及一个新的α吡喃酮衍生物,zofiellone(4),已经从内生真菌的培养物中分离Zopfiella藻。化合物2是稀有的trinor-bisabolane倍半萜类化合物,化合物3具有不寻常的芳香核。化合物34对三种人类癌细胞系具有轻度的细胞毒性,IC 50值范围为12.3–27.3μM。

更新日期:2020-04-15
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