Scalable Synthesis of Esp and Rhodium(II) Carboxylates from Acetylacetone and RhCl3·xH2O.,Organic Process Research & Development

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Scalable Synthesis of Esp and Rhodium(II) Carboxylates from Acetylacetone and RhCl3·xH2O.
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2020-04-14 , DOI: 10.1021/acs.oprd.0c00164
Elisa Martínez-Castro ₁ , Samuel Suárez-Pantiga ₁ , Abraham Mendoza ₁

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Rhodium(II) carboxylates are privileged catalysts for the most challenging carbene-, nitrene-, and oxo-transfer reactions. In this work, we address the strategic challenges of current organic and inorganic synthesis methods to access these rhodium(II) complexes through an oxidative rearrangement strategy and a reductive ligation reaction. These studies illustrate the multiple benefits of oxidative rearrangement in the process-scale synthesis of congested carboxylates over nitrile anion alkylation reactions, and the impressive effect of inorganic additives in the reductive ligation of rhodium(III) salts.

中文翻译：

由乙酰丙酮和RhCl3·xH2O合成可扩展的Esp和羧酸铑（II）。

羧酸铑（II）是最富挑战性的卡宾，氮烯和羰基转移反应的催化剂。在这项工作中，我们解决了当前有机和无机合成方法的战略挑战，这些方法是通过氧化重排策略和还原性连接反应来获得这些铑（II）配合物的。这些研究说明了氧化重排在拥挤的羧酸盐的过程规模合成中优于腈阴离子烷基化反应的多重好处，以及无机添加剂在铑（III）盐的还原性连接中的惊人作用。

更新日期：2020-06-19

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