Metabolic magnetic resonance imaging (MRI) using hyperpolarized [1‐¹³C]‐pyruvate offers unprecedented new insight into disease and response to therapy. ¹³C‐enriched reference standards are required to enable fast and accurate calibration for ¹³C studies, but care must be taken to ensure that the reference is compatible with both ¹³C and ¹H acquisitions. The goal of this study was to optimize the composition of a ¹³C‐urea reference for a dual‐tuned ¹³C/¹H endorectal coil and minimize imaging artifacts in metabolic and multiparametric MRI studies involving hyperpolarized [1‐¹³C]‐pyruvate.

中文翻译：

---

技术说明：用于临床多参数MRI前列腺癌研究（包括超极化丙酮酸）的氘代13 C-尿素参考。

使用超极化[1-代谢磁共振成像（MRI）¹³ C] -丙酮酸盐提供了前所未有的新洞察疾病和对治疗的反应。需要使用富含¹³ C的参比标准品以实现¹³ C研究的快速准确校准，但必须注意确保该参比与¹³ C和¹ H采集均兼容。本研究的目标是优化的组合物¹³ C尿素参考用于双调谐¹³ C / ¹ ħ直肠内线圈和最小化的代谢和多参数MRI研究成像伪影涉及超极化[1- ¹³ C] -丙酮酸盐。