Chartarlactams Q-T, Dimeric Phenylspirodrimanes with Antibacterial and Antiviral Activities,Chemistry & Biodiversity

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Chartarlactams Q-T, Dimeric Phenylspirodrimanes with Antibacterial and Antiviral Activities
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-06-01 , DOI: 10.1002/cbdv.202000170
Dong Liu ₁ , Yong Li ₁ , Xingchen Guo ₁ , Wei Ji ₂ , Wenhan Lin ₁

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Four new phenylspirodrimane‐type dimers, namely chartarlactams Q−T, along with stachyin B were isolated from the fermentation broth of a sponge‐derived fungus Stachybotrys chartarum WGC‐25 C‐6. Chartarlactams Q−T were structurally featured by the dimerization of two units of phenylspirodrimane linked by a C−N bond. Their structures were determined on the basis of extensive spectroscopic analysis, while quantum ECD calculation and modified Mosher's method were used for the assignment of absolute configurations. Chartarlactams Q−S and stachyin B showed moderate inhibition against bacterial pathogen Staphylococcus aureus with MIC values ranging from 4 μg/mL to 16 μg/mL, and chartarlactam T exhibited significant inhibition toward ZIKV virus.

中文翻译：

Chartarlactams QT，具有抗菌和抗病毒活性的二聚苯基螺环烷

从海绵来源真菌 Stachybotrys chartarum WGC-25 C-6 的发酵液中分离出四种新的苯基螺环烷型二聚体，即chartarlactams Q-T，以及水苏素 B。Chartarlactams Q-T 的结构特征是两个苯基螺环烷单元通过 CN 键连接的二聚化。它们的结构是在广泛的光谱分析的基础上确定的，而量子 ECD 计算和改进的 Mosher 方法用于分配绝对构型。Chartarlactams Q-S 和 stachyin B 对细菌病原体金黄色葡萄球菌表现出中等抑制作用，MIC 值范围为 4 μg/mL 至 16 μg/mL，chartarlactam T 对 ZIKV 病毒表现出显着抑制作用。

更新日期：2020-06-01

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