This research reported the design and synthesis of some influential new pyrrolone derivatives bearing a pyrazole scaffold with the evaluation of their antiviral activity against Newcastle disease virus (NDV) in specific pathogen free (SPF) chicken embryos and immune boosting properties of these substances in SPF chicks. The building block synthon was the pyrazolyl acid hydrazide, derived from 2(3H)-furanone, which was reacted with some carbonyl compounds, e.g., salicylaldehyde, furfural, 1,3-diphenylpyrazole-4-carbaldehyde, 2-chloroquinoline-3-carbaldehyde, chromone-3-carbaldehyde, and 3-acetylcoumarin. The results revealed that pyrazole derivative 6, quinoline derivatives 7 and 8 exhibited 100% protection against NDV while the hydroxyphenyl derivative 3 showed 95% protection. In turn, chromone derivative 10 and coumarin derivative 11 exhibited 90% protection. The structures of all products were established on the basis of their elemental analyses and spectroscopic techniques.

中文翻译：

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某些吡咯基取代杂环作为增强失活新城疫疫苗添加剂的合成及抗病毒活性

这项研究报告了一些具有吡唑支架的有影响力的新吡咯烷酮衍生物的设计与合成，并评估了它们在无特定病原体（SPF）的鸡胚中对新城疫病毒（NDV）的抗病毒活性以及这些物质在SPF雏鸡中的免疫增强特性。结构单元合成子是由2（3 H）-呋喃酮衍生的吡唑基酰肼，其与一些羰基化合物反应，例如水杨醛，糠醛，1,3-二苯基吡唑-4-甲醛，2-氯喹啉-3-甲醛，苯并三甲酮色原和3-乙酰香豆素。结果表明，吡唑衍生物6，喹啉衍生物7和8表现出对NDV的100％保护，而羟苯基衍生物3表现出95％的保护。反过来，色酮衍生物10和香豆素衍生物11表现出90％的保护作用。所有产品的结构都是根据其元素分析和光谱技术确定的。