Fibrosis is widely observed in multiple organs, which is generally associated with aging-related diseases, including liver fibrosis, lung fibrosis, cardiac fibrosis and renal fibrosis. The excess deposition of extracellular matrix ultimately leads to the disruption of organ architecture and loss of function. H19 is paternally imprinted maternally expressed lncRNA, which is highly expressed during the development of embryo but quickly downregulated after birth. Recently, a growing body of studies indicates that H19 is widely involved in the pathologic mechanism of fibrosis in various organs. In this review, we summarized current studies of H19 in fibrosis and hopefully aid in a better understanding of the molecular mechanism of fibrosis and the potential of H19 as novel therapeutic target for fibrosis.

中文翻译：

---

lncRNA H19在纤维化中的机制及其作为新治疗靶点的潜力。

纤维化广泛存在于多个器官，通常与衰老相关疾病有关，包括肝纤维化、肺纤维化、心脏纤维化和肾纤维化。细胞外基质的过度沉积最终导致器官结构的破坏和功能的丧失。H19是父系印记母系表达的lncRNA，在胚胎发育过程中高度表达，但在出生后迅速下调。最近，越来越多的研究表明 H19 广泛参与各种器官纤维化的病理机制。在这篇综述中，我们总结了 H19 在纤维化中的当前研究，并希望有助于更好地了解纤维化的分子机制和 H19 作为纤维化新治疗靶点的潜力。