Abstract Phytochemical analysis of isolates from the aerial parts of Clausena lansium Lour. Skeels (Rutaceae) led to the identification of 14 alkaloids, including two indole alkaloids (1 and 2), one quinoline alkaloid (3), two pyridine alkaloids (4 and 5), four carbazole alkaloids (6–9) and five amides alkaloids (10–14). The phytochemical structures of the alkaloids were established by means of NMR and MS spectral analyses. Compounds (4, 5, 14) were three new natural products, while 1–3 and 10 were firstly reported from the genus Clausena and 8 and 9 were isolated from this species for the first time. The chemotaxonomic significance of these isolated alkaloids has also been discussed. All the isolated alkaloids were tested for their cytotoxic activity against Hela cancer cell line. Among them, four carbazole alkaloids 6–9 exhibited weak cytotoxicity with IC50 values ranging from 69.31 to 138.32 μM.

中文翻译：

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Clausena lansium Lour 生物碱的分类学意义和抗肿瘤活性。龙骨（芸香科）

摘要 Clausena lansium Lour 地上部分分离物的植物化学分析。Skeels（芸香科）鉴定了 14 种生物碱，包括两种吲哚生物碱（1 和 2）、一种喹啉生物碱（3）、两种吡啶生物碱（4 和 5）、四种咔唑生物碱（6-9）和五种酰胺生物碱(10-14)。生物碱的植物化学结构是通过核磁共振和质谱分析确定的。化合物(4, 5, 14)为3个新的天然产物，其中1-3和10为Clausena属首次报道，8和9为首次从该种中分离得到。还讨论了这些分离的生物碱的化学分类学意义。测试了所有分离的生物碱对 Hela 癌细胞系的细胞毒活性。他们之中，