With the increasing awareness about the contamination of the aquatic environment by pharmaceuticals, there is a growing need to study their adverse effects on aquatic organisms. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID), whose wide use contributes for its presence in freshwater ecosystems, increasing the probability of causing deleterious changes in aquatic biota. This study evaluated possible oxidative stress effects in Danio rerio embryos and larvae when exposed to a range of ecologically relevant concentrations of diclofenac. It was possible to conclude that diclofenac caused a scenario of oxidative stress, since all tested toxicological parameters were responsive to the drug. In general, diclofenac caused not only significant anti-oxidant adaptive responses for most levels of exposure, but also peroxidative damage. This work evidenced the responsiveness of D. rerio towards diclofenac in environmentally relevant concentrations, which shows that these organisms might face a scenario of oxidative stress in their natural habitat.

随着人们越来越意识到药物对水环境的污染，越来越需要研究其对水生生物的不利影响。双氯芬酸是一种非甾体类抗炎药（NSAID），其广泛使用有助于其在淡水生态系统中的存在，从而增加了引起水生生物体有害变化的可能性。这项研究评估了Danio rerio中可能的氧化应激效应胚胎和幼虫暴露于一系列与生态有关的双氯芬酸浓度时。可以得出结论，双氯芬酸会引起氧化应激，因为所有测试的毒理学参数对药物都有反应。通常，双氯芬酸不仅在大多数暴露水平下引起明显的抗氧化适应性反应，而且还引起过氧化损伤。这项工作证明的响应D.鱼对双氯芬酸环境有关的浓度，这表明这些生物可能面临的氧化应激的情况下在其自然栖息地。