Myeloid-derived suppressor cells (MDSCs) can promote tumor progression. In this issue of Immunity, Mohamed et al. show that the unfolded protein response sensor, PERK, enhances MDSC-mediated immunosuppression through the NRF2 transcription factor, preventing oxidative damage, mitochondrial DNA release, and DNA sensor-STING-dependent type I interferon production.

中文翻译：

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减少压力PERK可提高抗肿瘤免疫力。

骨髓来源的抑制细胞（MDSC）可以促进肿瘤进展。在本期《免疫》中，Mohamed等人。结果表明，展开的蛋白质反应传感器PERK通过NRF2转录因子增强MDSC介导的免疫抑制，防止氧化损伤，线粒体DNA释放和DNA传感器-STING依赖的I型干扰素产生。