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Reducing Stress PERKs up Anti-tumor Immunity.
Immunity ( IF 25.5 ) Pub Date : 2020-04-14 , DOI: 10.1016/j.immuni.2020.03.012
Marie-Eve Charbonneau 1 , Mary X D O'Riordan 1
Affiliation  

Myeloid-derived suppressor cells (MDSCs) can promote tumor progression. In this issue of Immunity, Mohamed et al. show that the unfolded protein response sensor, PERK, enhances MDSC-mediated immunosuppression through the NRF2 transcription factor, preventing oxidative damage, mitochondrial DNA release, and DNA sensor-STING-dependent type I interferon production.

中文翻译:

减少压力PERK可提高抗肿瘤免疫力。

骨髓来源的抑制细胞(MDSC)可以促进肿瘤进展。在本期《免疫》中,Mohamed等人。结果表明,展开的蛋白质反应传感器PERK通过NRF2转录因子增强MDSC介导的免疫抑制,防止氧化损伤,线粒体DNA释放和DNA传感器-STING依赖的I型干扰素产生。
更新日期:2020-04-21
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