Regulation of uterine genes during the peri-implantation period, and its relationship to the maternal brain in gestating mice.,Molecular Reproduction and Development

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Regulation of uterine genes during the peri-implantation period, and its relationship to the maternal brain in gestating mice.
Molecular Reproduction and Development ( IF 2.7 ) Pub Date : 2020-03-22 , DOI: 10.1002/mrd.23338
Susanta K Behura _{1,

2} , Andrew M Kelleher ₁ , Thomas E Spencer _{1,

3}

Affiliation

We conducted an integrated analysis of gene expression and chromatin structure of mouse uterus to understand the regulation of uterine-expressed genes on gestation day 4 (GD4) during the peri-implantation period. The genes expressed in the uterus showed a significant association (p < .0001) with the presence of the nucleosome-free region (open chromatin) in the 5'-untranslated region of the genes. The majority of these upstream open chromatins harbored a common class of regulatory elements known as upstream open reading frames. We also compared the gene expression profiles between the uterus and brain which showed that specific gene pairs were expressed in a correlated manner, either positively or negatively. In addition, specific ligand/receptor genes showed coordinated patterns of expression between the uterus and brain on GD4, and the level of expression of these ligand/receptors altered significantly in the brain during late pregnancy (GD15) compared with the peri-implantation period (GD4). Collectively, these results suggest that regulation of the uterine genes during the peri-implantation period is likely to have a functional link with the maternal brain in pregnant mice.

中文翻译：

围着床期子宫基因的调控及其与妊娠小鼠母体大脑的关系。

我们对小鼠子宫的基因表达和染色质结构进行了综合分析，以了解围着床期妊娠第 4 天 (GD4) 子宫表达基因的调控。子宫中表达的基因与基因 5'-非翻译区中无核小体区（开放染色质）的存在显着相关（p < .0001）。这些上游开放染色质中的大多数都含有一类常见的调控元件，称为上游开放阅读框。我们还比较了子宫和大脑之间的基因表达谱，这表明特定基因对以相关的方式表达，无论是正的还是负的。此外，特定的配体/受体基因在 GD4 上显示出子宫和大脑之间的协调表达模式，与围着床期 (GD4) 相比，这些配体/受体的表达水平在妊娠晚期 (GD15) 的大脑中发生了显着变化。总的来说，这些结果表明，在胚胎着床期对子宫基因的调节可能与怀孕小鼠的母体大脑有功能联系。

更新日期：2020-03-22

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