Listening to mother: Long-term maternal effects in mammalian development.,Molecular Reproduction and Development

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Listening to mother: Long-term maternal effects in mammalian development.
Molecular Reproduction and Development ( IF 2.7 ) Pub Date : 2020-03-22 , DOI: 10.1002/mrd.23336
Meghan L Ruebel ₁ , Keith E Latham ₁

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The oocyte is a complex cell that executes many crucial and unique functions at the start of each life. These functions are fulfilled by a unique collection of macromolecules and other factors, all of which collectively support meiosis, oocyte activation, and embryo development. This review focuses on the effects of oocyte components on developmental processes that occur after the initial stages of embryogenesis. These include long-term effects on genome function, metabolism, lineage allocation, postnatal progeny health, and even subsequent generations. Factors that regulate chromatin structure, genome programming, and mitochondrial function are elements that contribute to these oocyte functions.

中文翻译：

听母亲的话：母体在哺乳动物发育中的长期影响。

卵母细胞是一个复杂的细胞，在每个生命的开始时都会执行许多至关重要的独特功能。这些功能通过独特的大分子和其他因子集合来实现，所有这些因子共同支持减数分裂，卵母细胞活化和胚胎发育。这篇综述集中在卵母细胞成分对胚胎发生初期后发生的发育过程的影响。这些包括对基因组功能，代谢，谱系分配，产后子代健康，甚至后代的长期影响。调节染色质结构，基因组程序和线粒体功能的因素是有助于这些卵母细胞功能的要素。

更新日期：2020-03-22

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