Candida albicans has emerged as a major public health problem in recent decades. The most important contributing factor is the rapid increase in resistance to conventional drugs worldwide. Synthetic antimicrobial peptides (SAMPs) have attracted substantial attention as alternatives and/or adjuvants in therapeutic treatments due to their strong activity at low concentrations without apparent toxicity. Here, two SAMPs, named Mo‐CBP₃‐PepI (CPAIQRCC) and Mo‐CBP₃‐PepII (NIQPPCRCC), are described, bioinspired by Mo‐CBP₃, which is an antifungal chitin‐binding protein from Moringa oleifera seeds. Furthermore, the mechanism of anticandidal activity was evaluated as well as their synergistic effects with nystatin. Both peptides induced the production of reactive oxygen species (ROS), cell wall degradation, and large pores in the C. albicans cell membrane. In addition, the peptides exhibited high potential as adjuvants because of their synergistic effects, by increasing almost 50‐fold the anticandidal activity of the conventional antifungal drug nystatin. These peptides have excellent potential as new drugs and/or adjuvants to conventional drugs for treatment of clinical infections caused by C. albicans.

中文翻译：

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合成肽的抗候选活性：通过扫描电子和荧光显微镜检查以及制霉菌素的协同作用揭示了作用机理。

近几十年来，白色念珠菌已成为主要的公共卫生问题。最重要的因素是全世界对常规药物的耐药性迅速增加。合成抗菌肽（SAMPs）作为替代品和/或佐剂在治疗方法中引起了广泛的关注，因为它们在低浓度下具有很强的活性而没有明显的毒性。在此，我们描述了两种SAMP，分别是Mo‐ CBP _3‐ PepI（CPAIQRCC）和Mo‐ CBP _3‐ PepII（NIQPPCRCC），它们受Mo‐ CBP _3的生物启发，Mo‐ CBP ₃是辣木的抗真菌几丁质结合蛋白。种子。此外，评估了抗候选活性的机理以及它们与制霉菌素的协同作用。两种肽均可诱导活性氧（ROS）的产生，细胞壁降解以及白色念珠菌细胞膜中的 大孔。此外，由于它们的协同作用，该肽通过将常规抗真菌药物制霉菌素的抗癌活性提高了近50倍，因此具有很高的佐剂潜力。这些肽作为用于治疗由白色念珠菌引起的临床感染的新药和/或常规药物的佐剂具有极好的潜力。