Integrated cardiorespiratory system model with short timescale control mechanisms,International Journal for Numerical Methods in Biomedical Engineering

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Integrated cardiorespiratory system model with short timescale control mechanisms
International Journal for Numerical Methods in Biomedical Engineering ( IF 2.2 ) Pub Date : 2020-03-18 , DOI: 10.1002/cnm.3332
Luciano G Fernandes _{1,

2} , Paulo R Trenhago _{2,

3} , Raúl A Feijóo _{2,

3} , Pablo J Blanco _{2,

3}

Affiliation

A compartmental model of the cardiorespiratory system featuring pulsatile blood flow and gas transport, as well as closed loop mechanisms of cardiorespiratory regulation is presented. Short timescale regulatory action includes baroreflex, peripheral and central chemoreflex feedback. The cardiorespiratory model is composed by compartments to describe blood flow and gas exchange in the major systemic and pulmonic regions. The control systems include formulations to afferent activity of arterial baroreceptor and peripheral and central chemoreceptors. Simulations described here include situations of hypoxia, hypercapnia, and hemorrhage. The overall responses of our simulations agree with physiological (experimental) and theoretical data. Our results suggest that the present model could be used to further understand the interplay among major regulatory mechanisms in the functioning of the cardiovascular and respiratory systems in cases of normal and abnormal physiological conditions.

中文翻译：

具有短时间尺度控制机制的综合心肺系统模型

介绍了具有脉动血流和气体运输的心肺系统的隔室模型，以及心肺调节的闭环机制。短期调节作用包括压力反射、外周和中枢化学反射反馈。心肺模型由隔室组成，用于描述主要全身和肺脏区域的血流和气体交换。控制系统包括对动脉压力感受器和外周和中枢化学感受器的传入活动的配方。此处描述的模拟包括缺氧、高碳酸血症和出血的情况。我们模拟的整体响应与生理（实验）和理论数据一致。

更新日期：2020-03-18

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