Optimization of porous stents for endovascular repair of abdominal aortic aneurysms.,International Journal for Numerical Methods in Biomedical Engineering

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Optimization of porous stents for endovascular repair of abdominal aortic aneurysms.
International Journal for Numerical Methods in Biomedical Engineering ( IF 2.2 ) Pub Date : 2020-04-17 , DOI: 10.1002/cnm.3336
Juan Stockle ₁ , David A Romero ₂ , Cristina H Amon _{2,

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Affiliation

This study presents a simulation‐based methodology to design porous stents to induce suitable hemodynamic environments inside abdominal aortic aneurysm (AAA) sacs. In the proposed methodology, an optimization algorithm iteratively modifies the porosity distribution of the stent and executes a computational fluid dynamics (CFD) simulation to determine the effect of these changes on the hemodynamic conditions inside the aneurysm sac. The optimization iterations proceed until relevant hemodynamic parameters are within ranges prescribed a priori by the user as desirable to control the progression of the AAA. The resulting porosity distribution uniquely describes the porous stent design that can control the hemodynamic environment (eg, shear stress at the aneurysm wall, pressure distribution, residence time), reducing AAA rupture risks and improving treatment efficacy. To demonstrate its potential, the proposed methodology is applied to idealized AAA geometry under steady‐state flow conditions, though it may be easily applied to more complex AAA geometries under transient, pulsatile flow conditions. The proposed methodology has the potential to enable the design of a new generation of porous stents tailored to patient‐specific geometries and flow conditions, to improve patient outcomes.

中文翻译：

多孔支架在腹主动脉瘤血管内修复中的优化。

这项研究提出了一种基于模拟的方法来设计多孔支架，以在腹主动脉瘤（AAA）囊内诱导合适的血液动力学环境。在提出的方法中，一种优化算法会迭代地修改支架的孔隙率分布，并执行计算流体力学（CFD）模拟，以确定这些变化对动脉瘤囊内部血液动力学状况的影响。进行优化迭代，直到相关的血液动力学参数在用户为控制AAA的进程所希望的，用户事先确定的范围内。最终的孔隙率分布独特地描述了可以控制血液动力学环境（例如，动脉瘤壁处的切应力，压力分布，停留时间）的多孔支架设计，降低AAA破裂风险并提高治疗效果。为了证明其潜力，尽管在瞬态，脉动流量条件下可以轻松地将其应用于更复杂的AAA几何体，但该方法仍可应用于稳态流动条件下的理想AAA几何体。所提出的方法学有可能实现针对患者特定的几何形状和血流条件定制的新一代多孔支架的设计，从而改善患者的预后。

更新日期：2020-04-17

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