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The highly interrelated GHRH, p53, and Hsp90 universe.
Cell Biology International ( IF 3.9 ) Pub Date : 2020-04-13 , DOI: 10.1002/cbin.11356
Nektarios Barabutis 1 , Agnieszka Siejka 2
Affiliation  

p53 universe is composed of a complex regulatory network, destined to counteract multifarious challenges threatening cell survival. Imbalance in those responses may result in human disease associated with inevitable consequences. The present work delivers our view of the corresponding phenomena, by involving the endothelium defender in meticulously orchestrated events against inflammatory stimuli. Immersing into the great depths of p53 cosmos may lead to promising therapies against devastating disorders, including acute respiratory distress syndrome.

中文翻译:

高度相关的GHRH,p53和Hsp90宇宙。

p53宇宙由复杂的监管网络组成,旨在应对威胁细胞存活的多种挑战。这些反应的不平衡可能导致人类疾病不可避免的后果。通过使内皮防御者参与精心策划的针对炎症刺激的事件,本工作提供了我们对相应现象的看法。深入p53宇宙的深处可能会导致针对破坏性疾病(包括急性呼吸窘迫综合征)的有前途的疗法。
更新日期:2020-04-13
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