Transient receptor potential vanilloid subfamily member 1 (TRPV1) is a nonselective cation channel, that is mainly distributed in sensory nerve endings and can release a variety of neurotransmitters after activation. Early studies showed that it mainly conducts pain sensation, but research has demonstrated that it also plays an important role in cardiovascular diseases. Notably, in atherosclerosis, the activation of TRPV1 can regulate lipid metabolism, reduce foam cell formation, protect endothelial cells, inhibit smooth muscle cell proliferation and inhibit inflammation and oxidation. In this review, the role of the TRPV1 channel in atherosclerosis was discussed to provide new ideas for the prevention and treatment of atherosclerotic diseases.

中文翻译：

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TRPV1通道在动脉粥样硬化中的作用。

瞬态受体电位香草样亚家族成员1（TRPV1）是非选择性阳离子通道，主要分布在感觉神经末梢，激活后可以释放多种神经递质。早期研究表明，它主要引起疼痛感，但研究表明，它在心血管疾病中也起着重要作用。值得注意的是，在动脉粥样硬化中，TRPV1的激活可调节脂质代谢，减少泡沫细胞形成，保护内皮细胞，抑制平滑肌细胞增殖并抑制炎症和氧化。在这篇综述中，讨论了TRPV1通道在动脉粥样硬化中的作用，为预防和治疗动脉粥样硬化疾病提供了新的思路。