Diabetes mellitus (DM) is a significant risk factor for peripheral artery disease (PAD). Patients with DM have two to four times the risk of developing PAD, and 20%–30% of all PAD patients have DM.¹ The complex aetiology and pathophysiology of DM associated with PAD are poorly understood; however, a myriad of inflammatory mediators in DM such as advanced glycation end products (AGEs), lipid peroxidation, and oxidative stress are all considered to contribute to PAD onset and progression. The pathobiology of PAD is further exacerbated by tissue ischaemia, endothelial dysfunction, and vascular inflammation.^2,3 The current treatment regimen is primarily lifestyle changes and drugs that target specific PAD/DM symptoms of cardiovascular, hypertensive, thrombotic, or limb-related comorbidities.^4,5

中文翻译：

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在糖尿病小鼠后肢缺血模型中，髓过氧化物酶的抑制作用可增加血运重建并改善血流。

糖尿病（DM）是周围动脉疾病（PAD）的重要危险因素。患有DM的患者患PAD的风险是其两倍至四倍，而所有PAD患者中有20％–30％患有DM。¹对与PAD相关的DM的复杂病因和病理生理了解甚少；但是，DM中无数的炎症介质（例如晚期糖基化终产物（AGEs），脂质过氧化和氧化应激）都被认为与PAD的发生和发展有关。组织缺血，内皮功能障碍和血管炎症会进一步加剧PAD的病理生物学。^2,3当前的治疗方案主要是改变生活方式和针对心血管，高血压，血栓形成或肢体相关合并症的特定PAD / DM症状的药物。^4,5