Mild traumatic brain injury (mTBI) is the most common (>80% cases) type of TBI within the military and civilian populations and is a major cause of disability and functional impairment. Epidemiological studies have reported that individuals exposed to a history of TBI are more susceptible to developing sporadic age-related neurodegenerative conditions in later life (Gedye et al., 1989; Mortimer et al., 1991; Fleminger et al., 2003; Li et al., 2017). The first clues linking TBI with pathological features of chronic neurodegenerative disease originated from studies reporting increased Aβ protein in the brains of patients who died acutely following TBI or in excised pericontusional injured tissue (Roberts et al., 1991, 1994; Ikonomovic et al., 2004; Dekosky et al., 2007). Neuroimaging studies with the amyloid sensitive Pittsburgh B compound have confirmed levels of amyloid beta in the gray matter and striata of TBI survivors comparable to mild cognitive impairment patients who go on to eventually develop dementia (Hong et al., 2014).

中文翻译：

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无偏见的蛋白质组学方法识别重复性轻度创伤性脑损伤、Tau蛋白病和淀粉样变性的临床前模型大脑中的病理生物学特征

轻度创伤性脑损伤 (mTBI) 是军人和平民中最常见的（>80% 病例）类型的 TBI，是导致残疾和功能障碍的主要原因。流行病学研究报告称，暴露于 TBI 病史的个体在晚年更容易患上与年龄相关的散发性神经退行性疾病（Gedye 等人，1989 年；Mortimer 等人，1991 年；Fleminger 等人，2003 年；Li 等人等，2017）。将 TBI 与慢性神经退行性疾病的病理特征联系起来的第一个线索来自研究报告称，在 TBI 后急性死亡的患者或切除的周围损伤组织中，Aβ 蛋白增加（Roberts 等人，1991 年，1994 年；Ikonomovic 等人， 2004 年；德科斯基等人，2007 年）。