Point-of-care (POC) testing has demonstrated great transformative potential in personalized medicine. In particular, patients undergoing transplantation require POC testing to ensure appropriate serum immunosuppressant levels so as to maintain adequate graft function and survival. However, no suitable POC device for monitoring immunosuppressant levels is currently available. Exploiting the latest advances in metamaterials can lead to a breakthrough in POC testing. A high-contrast grating (HCG) biosensor is a low-cost, compact, simple-to-fabricate, and easy-to-operate structure. It is highly sensitive and robust in surface-based biomarker detection, which is favorable for the efficiency of a POC device. In this study, the feasibility of using an HCG as a POC sensor for therapeutic drug monitoring of immunosuppressants was evaluated. The detection efficiency of the most commonly prescribed immunosuppressive medication cyclosporine A by using this sensor was demonstrated to be comparable to those of conventional commercial kits, suggesting that the sensor has the potential to be used as a rapid detection and feedback platform for increasing drug compliance and improving new organ transplant survival.

中文翻译：

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使用高对比度光栅作为用于免疫抑制剂治疗药物监测的护理点传感器的可行性


即时护理 (POC) 测试已在个性化医疗领域展现出巨大的变革潜力。特别是接受移植的患者需要进行POC检测，以确保适当的血清免疫抑制剂水平，以维持足够的移植物功能和存活。然而，目前还没有合适的 POC 设备来监测免疫抑制剂水平。利用超材料的最新进展可以带来 POC 测试的突破。高对比度光栅（HCG）生物传感器是一种低成本、紧凑、制造简单且易于操作的结构。它在基于表面的生物标志物检测中具有高度灵敏性和鲁棒性，这有利于 POC 设备的效率。在本研究中，评估了使用 HCG 作为 POC 传感器用于免疫抑制剂治疗药物监测的可行性。使用该传感器对最常用的免疫抑制药物环孢菌素 A 的检测效率被证明与传统商业试剂盒的检测效率相当，表明该传感器有潜力用作快速检测和反馈平台，以提高药物依从性和提高新器官移植的存活率。