To fine tune defense response output, plants recruit both positive and negative regulators. Here we report Arabidopsis DORMANCY/AUXIN ASSOCIATED FAMILY PROTEIN 2(DAP2) gene as a negative regulator of basal defense against virulent bacterial pathogens. Expression of DAP2 enhances upon pathogen inoculation. Our experiments show that DAP2 suppressed resistance against virulent strains of bacterial pathogens, pathogen-induced callose deposition, and ROS accumulation; however, it did not influence effector-triggered immunity. In addition, DAP2 negatively regulated systemic acquired resistance (SAR). DAP2 expression was enhanced in the pathogen-free systemic tissues of SAR-induced plants. Previously, Arabidopsis Flowering locus D (FLD) gene has been shown to be essential for SAR but not for local resistance. We show here that FLD function is necessary for SAR-induced expression of DAP2, suggesting DAP2 as a target of FLD for activation of SAR in Arabidopsis.

中文翻译：

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拟南芥的Dormancy / Auxin相关家族蛋白2是局部和全身获得性耐药的负调节剂。

为了微调防御响应的输出，工厂会同时招募正面和负面的监管者。在这里，我们报告拟南芥DORMANCY / AUXIN相关的家族蛋白2（DAP2）基因作为基础防御对有力细菌病原体的负调节器。DAP2的表达增强病原体接种。我们的实验表明，DAP2抑制了对细菌病原体的强毒株，病原体诱导的ose沉积和ROS积累的抗性。但是，它不影响效应子触发的免疫。此外，DAP2负调节全身获得性抵抗力（SAR）。DAP2表达在SAR诱导植物的无病原体系统组织中增强。以前，已经证明拟南芥开花基因座D（FLD）基因对于SAR是必不可少的，但对于局部耐药性却不是。