Aromatic prenyltransferases (PTases), including ABBA-type and dimethylallyl tryptophan synthase (DMATS)-type enzymes from bacteria and fungi, play important role for diversification of the natural products and improvement of the biological activities. For a decade, the characterization of enzymes and enzymatic synthesis of prenylated compounds by using ABBA-type and DMATS-type PTases have been demonstrated. Here, I introduce several examples of the studies on chemoenzymatic synthesis of unnatural prenylated compounds and the enzyme engineering of ABBA-type and DMATS-type PTases.

中文翻译：

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芳香异戊二烯基转移酶的酶学研究。

来自细菌和真菌的芳香异戊二烯基转移酶（PTases），包括ABBA型和二甲基烯丙基色氨酸合酶（DMATS）型酶，对天然产物的多样化和生物活性的改善起着重要的作用。十年来，已经证明了使用ABBA型和DMATS型PTase进行酶的表征和烯丙基化化合物的酶促合成。在这里，我介绍了一些化学实例，涉及非天然的烯丙基化化合物的化学合成以及ABBA型和DMATS型PTase的酶工程研究。