The remineralization approach mechanically occludes the exposed dentinal tubules mechanically, reduces the permeability of dentinal tubules and eliminates the symptoms of dentin hypersensitivity. The aim of the present study was to investigate the remineralization of demineralized dentin slices using CPP–ACP combined with TPP, and the research hypothesis was that CPP–ACP combined with TPP could result in extrafibrillar and intrafibrillar remineralization of dentin. Demineralized dentin slices were prepared and randomly divided into the following groups: A (the CPP–ACP group), B (the CPP–ACP + TPP combination group), C (the artificial saliva group), D (the negative control group), and E (the positive control group). Dentin slice samples from groups A, B and C were remineralized and the remineralization effect was evaluated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), attenuated total reflection–Fourier transform infrared spectroscopy (ATR–FTIR) and X-ray diffraction (XRD). Treatment with CPP–ACP combined with TPP occluded the dentinal tubules and resulted in remineralization of collagen fibrils. The hydroxyapatite crystals formed via remineralization were found to closely resemble the natural dentin components. CPP–ACP combined with TPP has a good remineralization effect on demineralized dentin slices.

中文翻译：

---

酪蛋白磷酸肽-无定形磷酸钙结合三聚磷酸钠再矿化牙本质片

再矿化方法机械地堵塞了暴露的牙本质小管，降低了牙本质小管的通透性并消除了牙本质过敏的症状。本研究的目的是研究使用CPP-ACP结合TPP进行脱矿质牙本质片的再矿化，研究假设是CPP-ACP结合TPP可能导致牙本质的原纤维化和原纤维化。准备去矿质的牙本质切片并将其随机分为以下各组：A（CPP-ACP组），B（CPP-ACP + TPP组合组），C（人工唾液组），D（阴性对照组），和E（阳性对照组）。A组的牙本质切片样品 B和C进行了再矿化，并使用扫描电子显微镜（SEM），透射电子显微镜（TEM），能量色散X射线光谱（EDX），衰减全反射-傅里叶变换红外光谱（ATR-FTIR）评估了再矿化效果和X射线衍射（XRD）。CPP-ACP与TPP联合治疗会阻塞牙本质小管，并导致胶原原纤维再矿化。发现通过再矿化形成的羟磷灰石晶体与天然牙本质组分非常相似。CPP-ACP与TPP结合使用对脱矿的牙本质片具有良好的再矿化作用。CPP-ACP与TPP联合治疗会阻塞牙本质小管，并导致胶原原纤维再矿化。发现通过再矿化形成的羟磷灰石晶体与天然牙本质组分非常相似。CPP-ACP与TPP结合使用对脱矿的牙本质片具有良好的再矿化作用。CPP-ACP与TPP联合治疗会阻塞牙本质小管，并导致胶原原纤维再矿化。发现通过再矿化形成的羟磷灰石晶体与天然牙本质组分非常相似。CPP-ACP与TPP结合使用对脱矿的牙本质片具有良好的再矿化作用。