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Qualitative assessment of EOB-GD-DTPA and Gd-BT-DO3A MR contrast studies in HCC patients and colorectal liver metastases
Infectious Agents and Cancer ( IF 3.1 ) Pub Date : 2019-11-27 , DOI: 10.1186/s13027-019-0264-3
Vincenza Granata 1 , Roberta Fusco 1 , Francesca Maio 2 , Antonio Avallone 3 , Guglielmo Nasti 3 , Raffaele Palaia 4 , Vittorio Albino 4 , Roberto Grassi 5 , Francesco Izzo 4 , Antonella Petrillo 1
Affiliation  

AimTo compare liver-specific EOB-GD-DTPA and liver-non-specific Gd-BT-DO3A MR, in hepatocellular carcinoma (HCC) and liver colorectal metastases.Material and methodsSeventy HCC patients with 158 nodules and 90 colorectal liver metastases (mCRC) with 370 lesions were included in the retrospective analysis. HCC patients underwent MR at 0 time (MR0), after 3 (MR3) and 6 months (MR6) using two different CM; 69 mCRC patients underwent MR with Gd-EOB-BTPA and 21 mCRC patients with Gd-BT-DO3A. We evaluated arterial phase hyperenhancement, lesion-to-liver contrast during portal phase, hepatobiliary phase parenchymal hyperenhancement.ResultsIn HCC patients arterial phase hyperenhancement degree was statistically higher (p = 0.03) with Gd-BT-DO3A (mean 4) than GD-EOB-DTPA (mean 2.6), while we found no significant statistical differences among mean (2.6) values at MR0 and MR6 using GD-EOB-DTPA. For all 209 patients underwent Gd-EOB-DTPA, we found that lesion-to-liver contrast during portal phase mean value was 4 while for patients underwent MR with Gd-BT-DO3A was 3 (p = 0.04). For HCC hepatobiliary phase parenchymal hyperenhancement mean value was 2.4. For mCRC patients: among 63 patients underwent previous chemotherapy hepatobiliary phase parenchymal hyperenhancement mean value was 3.1 while for 6 patients no underwent previous chemotherapy was 4 (p = 0.05).ConclusionsGd-EOB-DTPA should be chosen in pre surgical setting in patients with colorectal liver metastases.

中文翻译:

EOB-GD-DTPA 和 Gd-BT-DO3A MR 对比研究在 HCC 和结直肠肝转移中的定性评估

目的比较肝脏特异性 EOB-GD-DTPA 和肝脏非特异性 Gd-BT-DO3A MR 在肝细胞癌 (HCC) 和肝结直肠转移瘤中的作用。 材料和方法 70 例 HCC 患者 158 个结节和 90 个结直肠肝转移瘤 (mCRC)回顾性分析包括 370 个病灶。HCC 患者在 0 时间 (MR0)、3 (MR3) 和 6 个月 (MR6) 后使用两种不同的 CM 进行 MR;69 名 mCRC 患者接受了 Gd-EOB-BTPA 的 MR,21 名 mCRC 患者接受了 Gd-BT-DO3A。我们评估了动脉期高强化、门脉期病变与肝脏的对比、肝胆期实质高强化。结果在 HCC 患者中,Gd-BT-DO3A(平均 4)的动脉期高强化程度在统计学上高于 GD-EOB(平均 4)(p=0.03) -DTPA(平均值 2.6),而我们发现平均值(2. 6)MR0和MR6处的值使用GD-EOB-DTPA。对于所有 209 名接受 Gd-EOB-DTPA 的患者,我们发现门静脉期病变与肝脏的对比平均值为 4,而接受 Gd-BT-DO3A 的 MR 患者为 3 (p = 0.04)。HCC 肝胆期实质高强化的平均值为 2.4。对于 mCRC 患者:63 例接受过化疗的患者中,肝胆期实质高强化平均值为 3.1,而 6 例未接受过化疗的患者为 4(p = 0.05)。结论结直肠患者术前应选择 Gd-EOB-DTPA肝转移。HCC 肝胆期实质高强化的平均值为 2.4。对于 mCRC 患者:63 例接受过化疗的患者中,肝胆期实质高强化平均值为 3.1,而 6 例未接受过化疗的患者为 4(p = 0.05)。结论结直肠患者术前应选择 Gd-EOB-DTPA肝转移。HCC 肝胆期实质高强化的平均值为 2.4。对于 mCRC 患者:63 例接受过化疗的患者中,肝胆期实质高强化平均值为 3.1,而 6 例未接受过化疗的患者为 4(p = 0.05)。结论结直肠患者术前应选择 Gd-EOB-DTPA肝转移。
更新日期:2019-11-27
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