ObjectiveBreast cancer is one of the most common health problems. It has been suggested that several risk factors, either considered as external or internal, play a critical role in the pathogenesis of breast cancer, which among them, HERV-k, has the most fundamental role. In the present study, we aimed to evaluate the role of HERV-k env, gag, rec, np9 expressions in breast cancer progression.Materials and methodsWe collected 40 breast cancer tissues and their normal adjacent ones. After extracting the RNA of breast samples, we evaluated the expression of HERV-k env, gag, rec, np9 by using Quantitative real-time PCR (qRT-PCR).ResultsThe resulting data revealed that while there was a meaningful increase in the expression level of HERV-k env, gag and np9 in breast cancer tissues (P ≤ 0.01, 0.05, 0.05, respectively), we failed to find any significant elevation in the expression level of rec mRNA level.ConclusionThe results of our study suggested that there is a plausible correlation between the mRNA expression level of HERV-K env, gag and np9 and the progression of breast cancer, proposing these markers as promising biomarkers to diagnose breast cancer.

中文翻译：

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评估 HERV-K env、np9、rec 和 gag 在乳腺组织中的表达水平

目的 乳腺癌是最常见的健康问题之一。有人提出，几个风险因素，无论是外部的还是内部的，都在乳腺癌的发病机制中发挥着关键作用，其中 HERV-k 具有最基本的作用。在本研究中，我们旨在评估HERV-k env、gag、rec、np9表达在乳腺癌进展中的作用 材料与方法 我们收集了40个乳腺癌组织及其正常邻近组织。提取乳腺样本的 RNA 后，我们使用定量实时 PCR (qRT-PCR) 评估了 HERV-k env、gag、rec、np9 在乳腺癌组织中的表达水平。 （分别为 P ≤ 0.01、0.05、0.05），