Systemic lupus erythematosus (SLE) primarily affects women of childbearing age and is commonly seen in pregnancy. The physiologic and immunologic changes of pregnancy may alter the course of SLE and impact maternal, fetal, and neonatal health. Multidisciplinary counseling before and during pregnancy from rheumatology, maternal fetal medicine, obstetrics, and pediatric cardiology is critical. Transplacental passage of autoantibodies, present in about 40% of women with SLE, can result in neonatal lupus (NL). NL can consist of usually permanent cardiac manifestations, including conduction system and myocardial disease, as well as transient cutaneous, hematologic, and hepatic manifestations. Additionally, women with SLE are more likely to develop adverse pregnancy outcomes such as preeclampsia, fetal growth restriction, and preterm birth, perhaps due to an underlying effect on placentation. This review describes the impact of SLE on maternal and fetal health by trimester, beginning with prepregnancy optimization of maternal health. This is followed by a discussion of NL and the current understanding of the epidemiology and pathophysiology of anti‐Ro/La mediated cardiac disease, as well as screening, treatment, and methods for prevention. Finally discussed is the known increase in preeclampsia and fetal growth issues in women with SLE that can lead to iatrogenic preterm delivery.

中文翻译：

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对母体系统性红斑狼疮的胎儿和新生儿后果的回顾。

系统性红斑狼疮 (SLE) 主要影响育龄妇女，常见于妊娠期。妊娠的生理和免疫变化可能会改变 SLE 的病程并影响母体、胎儿和新生儿的健康。风湿病学、母胎医学、产科和儿科心脏病学在怀孕前和怀孕期间的多学科咨询至关重要。大约 40% 的 SLE 女性存在自身抗体的经胎盘通过，可导致新生儿狼疮 (NL)。NL 通常包括永久性心脏表现，包括传导系统和心肌疾病，以及短暂的皮肤、血液和肝脏表现。此外，患有 SLE 的女性更容易出现不良妊娠结局，例如先兆子痫、胎儿生长受限和早产，可能是由于对胎盘的潜在影响。本综述描述了 SLE 对孕期孕产妇和胎儿健康的影响，从孕前优化孕产妇健康开始。随后讨论了 NL 和目前对抗 Ro/La 介导的心脏病的流行病学和病理生理学的理解，以及筛查、治疗和预防方法。最后讨论的是已知会导致医源性早产的 SLE 女性先兆子痫和胎儿生长问题的增加。随后讨论了 NL 和目前对抗 Ro/La 介导的心脏病的流行病学和病理生理学的理解，以及筛查、治疗和预防方法。最后讨论的是已知会导致医源性早产的 SLE 女性先兆子痫和胎儿生长问题的增加。随后讨论了 NL 和目前对抗 Ro/La 介导的心脏病的流行病学和病理生理学的理解，以及筛查、治疗和预防方法。最后讨论的是已知会导致医源性早产的 SLE 女性先兆子痫和胎儿生长问题的增加。