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Combination use of tolfenamic acid with curcumin improves anti-inflammatory activity and reduces toxicity in mice.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-04-13 , DOI: 10.1111/jfbc.13240 Wei Zhou 1 , Qifa Liu 1 , Xiaohao Zang 1 , Mengmeng Hu 1 , Yuan Yue 1 , Yuchu Wang 1 , Chunyan Lv 2 , Zhiyun Du 1
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-04-13 , DOI: 10.1111/jfbc.13240 Wei Zhou 1 , Qifa Liu 1 , Xiaohao Zang 1 , Mengmeng Hu 1 , Yuan Yue 1 , Yuchu Wang 1 , Chunyan Lv 2 , Zhiyun Du 1
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Long‐term use of tolfenamic acid inevitably causes side effects, including gastric ulcer and hepatotoxicity. Curcumin is generally recognized to be anti‐inflammatory, hepatoprotective, and gastroprotective. Herein, we investigated the combinational effects of tolfenamic acid and curcumin and possible mechanism in a TPA‐induced inflammation mouse model. Combinational use of tolfenamic acid (100 mg/kg) and curcumin (100 mg/kg) by oral administration reduced dermal inflammation represented by ear edema and lymphocytic infiltration. Moreover, curcumin dispersed in polyvinyl pyrrolidone showed stronger synergistic effect. The beneficial effect of the coadministration was also reproduced in PKC/Akt/IKK/NF‐κB signaling pathways. Notably, hepatoprotective and gastroprotective effect was exhibited by the reverse of body weight loss and NF‐κB downregulation in the liver, and by increased Spleen Index of mice. These results suggested combination administration of tolfenamic acid with curcumin enhances anti‐inflammatory efficacy and reduces hepatic/gastric toxicity, which indicates dietary uptake of curcumin may facilitate the function of tolfenamic acid.
中文翻译：
结合使用甲苯磺酸和姜黄素可改善抗炎活性并降低小鼠毒性。
长期使用甲苯磺那酸不可避免地会引起副作用，包括胃溃疡和肝毒性。姜黄素通常被认为具有抗炎，保肝和保胃作用。在本文中，我们研究了甲苯戊酸和姜黄素的联合作用以及在TPA诱导的炎症小鼠模型中的可能机制。口服联合使用甲苯磺那酸（100 mg / kg）和姜黄素（100 mg / kg）可减少以耳水肿和淋巴细胞浸润为代表的皮肤炎症。此外，姜黄素分散在聚乙烯吡咯烷酮中显示出更强的协同作用。在PKC / Akt / IKK /NF-κB信号通路中也重现了共同给药的有益作用。值得注意的是 肝脏中体重减轻和NF-κB下调的逆转以及小鼠脾脏指数的升高显示出肝保护和胃保护作用。这些结果表明，将甲苯磺那酸与姜黄素联合给药可增强抗炎功效，并降低肝/胃毒性，这表明饮食中摄取姜黄素可能有助于甲苯磺那酸的功能。
更新日期：2020-04-13
中文翻译：
结合使用甲苯磺酸和姜黄素可改善抗炎活性并降低小鼠毒性。
长期使用甲苯磺那酸不可避免地会引起副作用，包括胃溃疡和肝毒性。姜黄素通常被认为具有抗炎，保肝和保胃作用。在本文中，我们研究了甲苯戊酸和姜黄素的联合作用以及在TPA诱导的炎症小鼠模型中的可能机制。口服联合使用甲苯磺那酸（100 mg / kg）和姜黄素（100 mg / kg）可减少以耳水肿和淋巴细胞浸润为代表的皮肤炎症。此外，姜黄素分散在聚乙烯吡咯烷酮中显示出更强的协同作用。在PKC / Akt / IKK /NF-κB信号通路中也重现了共同给药的有益作用。值得注意的是 肝脏中体重减轻和NF-κB下调的逆转以及小鼠脾脏指数的升高显示出肝保护和胃保护作用。这些结果表明，将甲苯磺那酸与姜黄素联合给药可增强抗炎功效，并降低肝/胃毒性，这表明饮食中摄取姜黄素可能有助于甲苯磺那酸的功能。
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