Double Emulsion‐Templated Single‐Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification,ChemNanoMat

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Double Emulsion‐Templated Single‐Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification
ChemNanoMat ( IF 2.6 ) Pub Date : 2020-04-29 , DOI: 10.1002/cnma.202000175
Xiangming Na ₁ , Jianjun Guo ₂ , Tong Li ₂ , Weiqing Zhou ₃ , Guanghui Ma ₁

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A scalable and versatile strategy was developed for fabrication of double emulsion‐templated single‐core PLGA microcapsules with narrow size distribution and controllable structure. A single‐core water‐in‐oil‐in‐water (W₁/O/W₂) double emulsion was generated from two‐step premix membrane emulsification, which guaranteed the narrow size distribution and size controllability of emulsion. During a secondary emulsification process, coalescence of W₁ droplets within oil droplet allowed multi‐core W₁/O/W₂ double emulsion to spontaneously transform to a single‐core one. The osmotic pressure and solvent diffusion rate were used to control the shell‐thickness and surface morphology of single‐core PLGA microcapsules, respectively. The method proposed in this study could be extended for the fabrication of uniform single‐core polymeric microcapsules with controllable structures and size.

中文翻译：

预混膜乳化法制备具有窄尺寸分布和可控结构的双乳液模板单核PLGA微胶囊

开发了一种可扩展的通用策略，用于制备尺寸分布窄且结构可控的双乳液模板单核PLGA微胶囊。两步预混膜乳化产生了单芯水包水（W ₁ / O / W ₂）双乳状液，从而保证了乳状液的窄粒度分布和尺寸可控性。在二次乳化过程中，油滴中的W ₁滴聚结形成了多核W ₁ / O / W ₂双重乳液可自发转变为单核乳液。渗透压和溶剂扩散速率分别用于控制单核PLGA微胶囊的壳厚度和表面形态。这项研究中提出的方法可以扩展到具有可控制的结构和大小的均匀单核聚合物微胶囊的制造。

更新日期：2020-04-29

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