Purpose

Binovular follicles including a pair of conjoined oocytes within a common zona pellucida or their fusion in the zonal region gained some attentions due to its possible role in dizygotic twins. Although some cases in the literature been reported in which two conjoined oocytes arising from binovular follicles were mature, and injected with two separated sperm, no available evidence reported for dizygotic twin pregnancies.

Methods

A case report of a 37-year-old female patient underwent embryo transfer cycle whereby a pair of conjoined blastocysts after ICSI of a pair of conjoined oocytes was transferred.

Results

The β-hCG level was positive 15 days after embryo transfer. The subsequent pregnancy scan revealed a dizygotic pregnancy. The woman gave birth to two healthy boys in the mid of 38 weeks of gestation by cesarean section.

Conclusions

Given the insufficient evidence on how to handle conjoined oocytes, this report acknowledges the first occurrence of dizygotic twin delivery resulted from transfer of a pair of conjoined blastocysts after ICSI of a pair of conjoined oocytes. This also confirms that we should be extremely conservative in discarding any mature oocyte without sufficient data about its useless future to result in a healthy baby.

中文翻译：

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来自连体卵母细胞的异卵双胞胎：病例报告。

目的

双卵卵泡包括位于共同透明带内的一对连体卵母细胞或它们在带状区域中的融合，由于其在异卵双胞胎中可能发挥的作用而引起了一些关注。尽管文献中报道了一些案例，其中双卵卵泡产生的两个连体卵母细胞成熟，并注射了两个分离的精子，但没有关于异卵双胞胎妊娠的可用证据报道。

方法

一名 37 岁女性患者接受胚胎移植周期的病例报告，在一对连体卵母细胞 ICSI 后移植了一对连体囊胚。

结果

胚胎移植后15天β-hCG水平呈阳性。随后的妊娠扫描显示双卵妊娠。这名妇女在怀孕38周中期通过剖腹产产下了两个健康的男孩。

结论

鉴于如何处理连体卵的证据不足，本报告承认首次发生异卵双胞胎是由于一对连体卵母细胞 ICSI 后移植一对连体囊胚所致。这也证实，如果没有足够的数据表明其未来无用，无法产生健康的婴儿，我们在丢弃任何成熟的卵母细胞时应该极其保守。