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Role of epoxyeicosatrienoic acids in the lung.
ProstaglandIns & Other Lipid Mediators ( IF 2.5 ) Pub Date : 2020-04-12 , DOI: 10.1016/j.prostaglandins.2020.106451 Hugo F Olivares-Rubio 1 , J J Espinosa-Aguirre 1
ProstaglandIns & Other Lipid Mediators ( IF 2.5 ) Pub Date : 2020-04-12 , DOI: 10.1016/j.prostaglandins.2020.106451 Hugo F Olivares-Rubio 1 , J J Espinosa-Aguirre 1
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Epoxyeicosatrienoic acids (EETs) are synthetized from arachidonic acid by the action of members of the CYP2C and CYP2J subfamilies of cytochrome P450 (CYPs). The effects of EETs on cardiovascular function, the nervous system, the kidney and metabolic disease have been reviewed. In the lungs, the presence of these CYPs and EETs has been documented. In general, EETs play a beneficial role in this essential tissue. Among the most important effects of EETs in the lungs are the induction of vasorelaxation in the bronchi, the stimulation of Ca2+-activated K+ channels, the induction of vasoconstriction of pulmonary arteries, anti-inflammatory effects induced by asthma, and protection against infection or exposure to chemical substances such as cigarette smoke. EETs also participate in tissue regeneration, but on the downside, they are possibly involved in the progression of lung cancer. More research is necessary to design therapies with EETs for the treatment of lung disease.
中文翻译：
环氧二十碳三烯酸在肺中的作用。
环氧二十碳三烯酸（EETs）是通过花生四烯酸通过细胞色素P450（CYPs）的CYP2C和CYP2J亚家族成员的作用合成的。EETs对心血管功能，神经系统，肾脏和代谢性疾病的影响已得到综述。在肺中，这些CYP和EET的存在已被记录。通常，EET在该基本组织中起有益作用。EET对肺部最重要的作用是诱导支气管舒张，刺激Ca2 +激活的K +通道，诱导肺动脉血管收缩，哮喘引起的抗炎作用以及防止感染或暴露去香烟等化学物质。EET也参与组织再生，但不利的是，它们可能与肺癌的进展有关。设计用于治疗肺部疾病的EET疗法需要更多的研究。
更新日期：2020-04-13
中文翻译：
环氧二十碳三烯酸在肺中的作用。
环氧二十碳三烯酸（EETs）是通过花生四烯酸通过细胞色素P450（CYPs）的CYP2C和CYP2J亚家族成员的作用合成的。EETs对心血管功能，神经系统，肾脏和代谢性疾病的影响已得到综述。在肺中，这些CYP和EET的存在已被记录。通常，EET在该基本组织中起有益作用。EET对肺部最重要的作用是诱导支气管舒张，刺激Ca2 +激活的K +通道，诱导肺动脉血管收缩，哮喘引起的抗炎作用以及防止感染或暴露去香烟等化学物质。EET也参与组织再生，但不利的是，它们可能与肺癌的进展有关。设计用于治疗肺部疾病的EET疗法需要更多的研究。
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