Objective

Exercise-induced changes in the neurotrophic factors and the physical function are essential for the rehabilitation of the multiple sclerosis (MS) persons. The aim of this study was investigating of effectiveness of the combined functional training (CFT) on brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and their association with health-related fitness in the MS women.

Design

Twenty women with relapsing-remitting MS randomly assigned to CFT and control (CON) groups. The CFT consisted of 8 weeks (3 days per week) rhythmic aerobic exercise, TRX suspension training, elastic band training, and bodyweight training. BDNF, IGF-1, and health-related fitness components were assessed before and after the intervention.

Results

There was no significant difference in BDNF level between the CFT and the CON group. In contrast, IGF-1, walking speed, and strength of the right- and left-hand was significantly increased in the CFT compared with the CON group. Furthermore, there was a significant and positive correlation between IGF-1 and some fitness components.

Conclusions

The findings indicated that CFT might a useful training mode in the rehabilitation of the MS women. CFT improved IGF-1 level that is a neuroprotective agent in MS. Positive and significant association between IGF-1 and some health-related fitness components indicates of the importance of IGF-1 in the rehabilitation of the MS persons than BDNF.

中文翻译：

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联合功能训练对多发性硬化症女性 BDNF、IGF-1 的影响及其与健康相关健身的关系。

 客观的

运动引起的神经营养因子和身体功能的变化对于多发性硬化症（MS）患者的康复至关重要。本研究的目的是调查联合功能训练 (CFT) 对脑源性神经营养因子 (BDNF)、胰岛素样生长因子-1 (IGF-1) 的有效性，以及它们与健康相关健身的关系。女士女士。

 设计

20 名患有复发缓解型多发性硬化症的女性​​被随机分配到 CFT 组和对照组 (CON)。 CFT包括8周（每周3天）节奏有氧运动、TRX悬吊训练、弹力带训练和自重训练。在干预前后评估 BDNF、IGF-1 和健康相关的健身成分。

 结果

CFT组和CON组之间BDNF水平没有显着差异。相反，与 CON 组相比，CFT 组的 IGF-1、步行速度和左右手力量显着增加。此外，IGF-1 和一些健身成分之间存在显着的正相关关系。

 结论

研究结果表明，CFT 可能是 MS 女性康复的一种有用的训练模式。 CFT 提高了 IGF-1 水平，IGF-1 是多发性硬化症的神经保护剂。 IGF-1 和一些与健康相关的健身成分之间的正相关和显着关联表明 IGF-1 在 MS 患者的康复中比 BDNF 更重要。