Omadacycline and tigecycline MIC90 values were 2 μg/mL and 0.25 μg/mL, respectively, against Staphylococcus aureus carrying tet(M), whereas the minocycline, tetracycline, and doxycycline values were > 8 μg/mL. Similarly, omadacycline and tigecycline remained active against Enterococcus faecalis and Streptococcus pneumoniae harboring tet(L)and/or tet(M)(MIC90, 0.06-0.25 μg/mL), whereas other tetracyclines were inactive (MIC90, >8 μg/mL). Omadacycline and tigecycline remained more potent than minocycline, tetracycline, and doxycycline against Enterobacteriaceae carrying tet. This study demonstrates the effectiveness of modern tetracyclines, omadacycline, and tigecycline against isolates with tetracycline resistance genes.

中文翻译：

---

Omadacycline对具有已知获得性四环素抗性机制的临床分离株的分子表征的集合具有体外活性。

对于携带tet（M）的金黄色葡萄球菌，Omadacycline和tigecycline的MIC90值分别为2μg/ mL和0.25μg/ mL，而米诺环素，四环素和强力霉素的值均大于8μg/ mL。同样，奥马达环素和替加环素对带有tet（L）和/或tet（M）（MIC90，0.06-0.25μg/ mL）的粪便肠球菌和肺炎链球菌仍然有效，而其他四环素则无活性（MIC90，> 8μg/ mL） 。对于携带肠杆菌的tet，Omadacycline和tigecycline的效力比米诺环素，四环素和强力霉素高。这项研究证明了现代四环素，奥马达环素和替加环素对具有四环素抗性基因的分离株的有效性。