Research question

Is there an association between ovarian response and perinatal outcomes?

Design

A retrospective, single-centre cohort study including all women undergoing their first ovarian stimulation cycle in a gonadotrophin releasing hormone antagonist protocol, with a fresh embryo transfer that resulted in a singleton live birth from January 2009 to December 2015. Patients were categorized into four groups according to the number of oocytes retrieved: one to three (category 1), four to nine (category 2), 10–15 (category 3), or over 15 oocytes (category 4).

Results

The overall number of patients analysed was 964. No relevant statistical difference was found among neonatal outcomes across the four ovarian response categories. Neonatal weight (in grams) was comparable between all groups (3222 ± 607 versus 3254 ± 537 versus 3235 ± 575 versus 3200 ± 622; P = 0.85, in categories 1, 2, 3 and 4, respectively). No statistically significant differences were found among the ovarian response categories for birth weight z-scores (taking into account neonatal sex and delivery term). The incidence of pre-term birth and low birth weight was comparable across the different ovarian response groups (P = 0.127 and P = 0.19, respectively). Finally, the occurrence of adverse obstetric outcomes did not differ among the ovarian response categories. Multivariate regression analysis revealed that the number of oocytes was not associated with neonatal birth weight.

Conclusions

No association was found between ovarian response and adverse perinatal outcomes in antagonist IVF and intracytoplasmic sperm injection cycles. Future, larger scale and prospectively designed investigations are needed to validate these results.

中文翻译：

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在GnRH拮抗剂IVF / ICSI周期中，卵巢反应是否与围产期不良结果相关？

研究问题

卵巢反应与围产期结局之间有关联吗？

设计

一项回顾性单中心队列研究，包括所有在促性腺激素释放激素拮抗剂方案中经历了第一个卵巢刺激周期的妇女，并进行了新的胚胎移植，从2009年1月至2015年12月进行了单胎活产。患者分为四组根据取回的卵母细胞数量：一到三个（类别1），四到九（类别2），10-15（类别3）或超过15个卵母细胞（类别4）。

结果

分析的患者总数为964。在四个卵巢反应类别的新生儿结局之间均未发现相关的统计差异。两组之间的新生儿体重（以克计）相当（分别在1、2、3和4类中，3222±607对3254±537对3235±575对3200±622；P = 0.85）。在卵巢反应类别中，出生体重z评分（考虑到新生儿性别和分娩期）在统计学上没有发现显着差异。在不同的卵巢反应组中，早产和低出生体重的发生率具有可比性（P = 0.127和P分别为0.19）。最后，在卵巢反应类别之间，产科不良预后的发生没有差异。多元回归分析表明，卵母细胞数量与新生儿出生体重无关。

结论

在拮抗剂IVF和胞浆内精子注射周期中，卵巢反应与不良围生期结局之间未发现关联。为了验证这些结果，需要进行将来的，规模更大的和前瞻性设计的研究。