Endocrine-disrupting compounds (EDCs) are common contaminants in our environment that interfere with typical endocrine function. EDCs can act on steroid and nuclear receptors or alter hormone production. One particular EDC of critical concern is bisphenol A (BPA) due to its potential harm during the perinatal period of development. Previous studies suggest that perinatal exposure to BPA alters several neurotransmitter systems and disrupts behaviors associated with depression and anxiety in the rodent offspring later in life. Thus, dysregulation in neurotransmission may translate to behavioral phenotypes observed in mood and arousal. Many of the systems disrupted by BPA also overlap with the stress system, although little evidence exists on the effects of perinatal BPA exposure in relation to stress and behavior. The purpose of this review is to explore studies involved in perinatal BPA exposure and the stress response at neurochemical and behavioral endpoints. Although more research is needed, we suggest that perinatal BPA exposure is likely inducing variations in behavioral phenotypes that modulate their action through dysregulation of neurotransmitter systems sensitive to stress and endocrine disruption.

中文翻译：

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围产期在压力，焦虑和抑郁的交汇处接触双酚A。

破坏内分泌的化合物（EDC）是我们环境中的常见污染物，会干扰典型的内分泌功能。EDC可以作用于类固醇和核受体或改变激素的产生。双酚A（BPA）是一种特别令人关注的EDC，因为双酚A在围产期发育过程中可能会造成伤害。先前的研究表明，围产期接触双酚A会改变几种神经递质系统，并破坏与啮齿动物后代抑郁和焦虑相关的行为。因此，神经传递的失调可能转化为在情绪和唤醒中观察到的行为表型。尽管很少有证据表明围产期BPA暴露与压力和行为有关，但许多被BPA破坏的系统也与压力系统重叠。这篇综述的目的是探讨围产期BPA暴露以及神经化学和行为终点的应激反应的研究。尽管需要进行更多的研究，但我们认为围产期BPA暴露可能会引起行为表型的变异，从而通过对压力和内分泌干扰敏感的神经递质系统失调来调节其行为。