Risk factors of attacks in neuromyelitis optica spectrum disorders,Journal of Neuroimmunology

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Risk factors of attacks in neuromyelitis optica spectrum disorders
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-06-01 , DOI: 10.1016/j.jneuroim.2020.577236
Tetsuya Akaishi ₁ , Toshiyuki Takahashi ₂ , Kazuo Fujihara ₃ , Tatsuro Misu ₄ , Michiaki Abe ₅ , Tadashi Ishii ₅ , Masashi Aoki ₄ , Ichiro Nakashima ₆

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Predisposing factors before the onset of neuromyelitis optica spectrum disorders (NMOSD) have not been systematically evaluated by now. We investigated the detailed pre-onset history in consecutive NMOSD patients. Thirteen of the enrolled 53 NMOSD patients (24.5%) had accompanying autoimmune diseases, such as Sjögren's syndrome. History of malignancy was seen in 8 of the 53 patients (15.1%). Recent history of non-neurological clinical episodes, such as systemic allergic reaction, systemic infection, surgical operation, or traumatic injury, was seen in 23 of the 53 patients (43.4%). NMOSD patients are likely to have pre-onset history of other autoimmune diseases, malignancy, or recent non-neurological systemic conditions, which may predispose or trigger the onset of NMOSD.

中文翻译：

视神经脊髓炎谱系疾病发作的危险因素

目前尚未系统地评估视神经脊髓炎谱系疾病 (NMOSD) 发病前的诱发因素。我们调查了连续 NMOSD 患者的详细发病前病史。入组的 53 名 NMOSD 患者中有 13 名 (24.5%) 伴有自身免疫性疾病，如干燥综合征。53 名患者中有 8 名 (15.1%) 有恶性肿瘤史。53 名患者中有 23 名 (43.4%) 近期有非神经系统临床发作史，例如全身过敏反应、全身感染、外科手术或外伤。NMOSD 患者很可能有其他自身免疫性疾病、恶性肿瘤或近期非神经系统疾病的发病前病史，这可能会诱发或触发 NMOSD 的发病。

更新日期：2020-06-01

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