Anti-brain protein autoantibodies are detectable in extraparenchymal but not parenchymal neurocysticercosis,Journal of Neuroimmunology

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Anti-brain protein autoantibodies are detectable in extraparenchymal but not parenchymal neurocysticercosis
Journal of Neuroimmunology ( IF 2.9 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.jneuroim.2020.577234
R Michael E Parkhouse ₁ , Arturo Carpio ₂ , Maria Milagros Cortez ₃ , Alex von Kriegsheim ₄ , Constantin Fesel ₁

Affiliation

Neurocysticercosis (NC) presents a spectrum of clinical manifestations, with two broad clinical entities based on the central nervous system location of the parasite: extraparenchymal (EP-NC) and parenchymal (P-NC). In this work, using quantitative immunoblot methodology, we demonstrate the presence of autoantibodies to brain proteins in CSF from EP-NC, but not P-NC, patients. There was striking correlation between the level of autoantibodies and the levels of the secreted metacestode glycoprotein HP-10, suggesting that the level of stimulation of the autoantibody response may be a function of the number of viable parasites. Nine corresponding proteins autoantigens were provisionally identified by mass spectroscopy.

中文翻译：

抗脑蛋白自身抗体可在实质外但不是实质神经囊尾蚴病中检测到

神经囊尾蚴病 (NC) 表现出一系列临床表现，根据寄生虫的中枢神经系统位置具有两种广泛的临床实体：实质外 (EP-NC) 和实质 (P-NC)。在这项工作中，我们使用定量免疫印迹方法证明了 EP-NC 患者的脑脊液中存在针对脑蛋白的自身抗体，但不存在 P-NC 患者。自身抗体水平与分泌的metacestode糖蛋白HP-10水平之间存在惊人的相关性，表明自身抗体反应的刺激水平可能是活寄生虫数量的函数。通过质谱法暂时鉴定了九种相应的蛋白质自身抗原。

更新日期：2020-07-01

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