BACKGROUND There is limited data available on the safety of therapeutic plasma exchange (TPE) for paediatric neuro-immunological disorders (PNID). In this study, we report our data on safety and feasibility of TPE for these disorders. METHODS Retrospective chart review was performed to include all patient who received TPE for four major PNID conditions: autoimmune encephalitis (AIE), acute disseminated encephalomyelitis (ADEM), Neuromyelitis optic spectrum disorder (NMOSD) and transverse myelitis (TM). We recorded minor and major adverse effects (AEs) associated with each TPE procedure. Secondary analysis also looked at the efficacy data of TPE on these patients. RESULTS Thirty-two patients with PNID received a total of 186 TPE cycles. Out of these, only 1 cycle (0.89%) in AIE subgroup, 1 (4.3%) in NMOSD and 1 (4.5%) in TM had adverse effects. No patients had major side effects. CONCLUSION TPE was safe and well tolerated in our PNID patients.

中文翻译：

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儿科神经免疫学血浆置换的可行性和安全性：单中心经验

背景 关于治疗性血浆置换 (TPE) 治疗儿科神经免疫疾病 (PNID) 的安全性的可用数据有限。在这项研究中，我们报告了 TPE 治疗这些疾病的安全性和可行性数据。方法回顾性图表审查包括所有接受 TPE 治疗四种主要 PNID 疾病的患者：自身免疫性脑炎 (AIE)、急性播散性脑脊髓炎 (ADEM)、视神经脊髓炎视谱疾病 (NMOSD) 和横贯性脊髓炎 (TM)。我们记录了与每个 TPE 程序相关的次要和主要不良反应 (AE)。二级分析还研究了 TPE 对这些患者的疗效数据。结果 32 名 PNID 患者共接受了 186 个 TPE 周期。其中，AIE 亚组中只有 1 个周期 (0.89%)、NMOSD 中 1 个 (4.3%) 和 TM 中 1 个 (4.5%) 出现不良反应。没有患者出现严重的副作用。结论 TPE 在我们的 PNID 患者中是安全且耐受性良好的。