GDF15 is frequently detected in patients suffering from various diseases, especially those associated with pro-inflammatory processes and/or metabolic disorders. Accordingly, sepsis, whose major complications are related to metabolic alterations and systemic inflammation, significantly increases the secretion of GDF15. Indeed, this cytokine could be considered a marker of sepsis severity. However, until the last several years, the involvement of GDF15 in these disorders had not been widely characterized. In mice, GDF15 was recently described as a pivotal inducer of sepsis tolerance by mediating metabolic alterations that reduce tissue damage. In this work we describe a zebrafish gdf15 gene. We found that gdf15 follows an expression pattern similar to that observed in mammals, being highly expressed in the liver and kidney and induced after pro-inflammatory stimuli. Moreover, larvae overexpressing gdf15 were more resistant to bacterial and viral challenges without affecting the pathogen load. Consequently, Gdf15 also protected zebrafish larvae against LPS-induced mortality. As in mice, zebrafish Gdf15 seems to induce sepsis tolerance by altering the metabolic parameters of the individuals.

中文翻译：

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斑马鱼 (Danio rerio) Gdf15 作为败血症耐受介质的保守功能。

GDF15 经常在患有各种疾病的患者中检测到，尤其是那些与促炎过程和/或代谢紊乱相关的疾病。因此，败血症的主要并发症与代谢改变和全身炎症有关，显着增加 GDF15 的分泌。事实上，这种细胞因子可以被认为是败血症严重程度的标志。然而，直到最近几年，GDF15 在这些疾病中的参与还没有得到广泛的表征。在小鼠中，GDF15 最近被描述为通过介导减少组织损伤的代谢改变而导致败血症耐受的关键诱导剂。在这项工作中，我们描述了斑马鱼 gdf15 基因。我们发现 gdf15 遵循与在哺乳动物中观察到的相似的表达模式，在肝脏和肾脏中高度表达并在促炎刺激后诱导。此外，过表达 gdf15 的幼虫对细菌和病毒的攻击更具抵抗力，而不会影响病原体负荷。因此，Gdf15 还保护斑马鱼幼虫免受 LPS 诱导的死亡。与小鼠一样，斑马鱼 Gdf15 似乎通过改变个体的代谢参数来诱导败血症耐受。