Ethanamizuril, a new anticoccidial agent that belongs to triazine derivatives, has a broad and good anticoccidial activity. To evaluate the reproductive toxicity and teratogenic potential of ethanamizuril, different concentrations of ethanamizuril were administered to Sprague–Dawley rats by feeding diets containing 0, 2, 8, and 30 ppm, respectively. Each group consisting of 30 males and 30 females (F0) was treated with different concentrations of ethanamizuril through a 13‐week period before mating and during mating, gestation, parturition and lactation. In the 30 ppm dose group, pup body weight on days 7 and 21 in F1 offspring and day 21 in the F2a offspring were significantly decreased. A limited teratogenicity study was performed in combination with the F1 generation of a two‐generation reproduction study. F1 offspring of the reproduction study were mated after weaning of the F2a offspring. Pregnant female rats were subjected to cesarean section on gestational day 20 for teratogenic examination. No obvious body weights, fetal body lengths, tail lengths, litter weights, number of viable fetuses, external, skeletal, or visceral malformations in fetuses were noted in any groups in the teratogenic test, but ethanamizuril could be passed on to offspring through lactation.

中文翻译：

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喂给大鼠的乙那米脲的两代繁殖和有限的畸形学研究。

Ethanamizuril是一种新型抗球虫剂，属于三嗪衍生物，具有广泛而良好的抗球虫活性。为评估乙胺脲的生殖毒性和致畸潜力，分别通过饲喂含有 0、2、8 和 30 ppm 的饮食对 Sprague-Dawley 大鼠施用不同浓度的乙胺脲。每组由 30 名雄性和 30 名雌性 (F0) 组成，在交配前 13 周以及交配、妊娠、分娩和哺乳期间用不同浓度的乙胺脲治疗。在 30 ppm 剂量组中，F1 后代第 7 天和第 21 天以及 F2a 后代第 21 天的幼犬体重显着下降。一项有限的致畸性研究与两代繁殖研究的 F1 代相结合。繁殖研究的 F1 后代在 F2a 后代断奶后交配。孕母鼠于孕20天剖宫产进行致畸检查。在致畸试验中，任何组均未发现明显的体重、胎儿体长、尾长、窝重、存活胎儿数、外部、骨骼或内脏畸形，但乙胺珠脲可通过哺乳传给后代。