Macrophages, the major population of tissue‐resident mononuclear phagocytes, contribute significantly to the immune response during helminth infection. Alternatively activated macrophages (AAM) are induced early in the anti‐helminth response following tissue insult and parasite recognition, amplifying the early type 2 immune cascade initiated by epithelial cells and ILC2s, and subsequently driving parasite expulsion. AAM also contribute to functional alterations in tissues infiltrated with helminth larvae, mediating both tissue repair and inflammation. Their activation is amplified and occurs more rapidly following reinfection, where they can play a dual role in trapping tissue migratory larvae and preventing or resolving the associated inflammation and damage. In this review, we will address both the known and emerging roles of tissue macrophages during helminth infection, in addition to considering both outstanding research questions and new therapeutic strategies.

中文翻译：

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巨噬细胞和蠕虫之间的相互作用。

巨噬细胞是组织驻留的单核吞噬细胞的主要种群，在蠕虫感染过程中对免疫反应具有重要作用。或者，在组织损伤和寄生虫识别后的抗蠕虫反应的早期诱导活化的巨噬细胞（AAM），放大由上皮细胞和ILC2s引发的早期2型免疫级联反应，并随后驱赶寄生虫排出。AAM还有助于蠕虫幼虫浸润的组织功能改变，介导组织修复和炎症。它们的激活被放大并在重新感染后更快地发生，在它们中，它们在捕获组织迁移性幼虫以及预防或解决相关的炎症和损害中起着双重作用。在这篇评论中