Pallidal 1/f asymmetry in patients with cervical dystonia,European Journal of Neuroscience

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Pallidal 1/f asymmetry in patients with cervical dystonia
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-04-01 , DOI: 10.1111/ejn.14729
Ulia Semenova ₁ , Valentin Popov _{1,

2} , Alexey Tomskiy ₂ , Aasef G Shaikh _{3,

4,

5} , Alexey Sedov _{1,

6}

Affiliation

Lateralized differences in pallidal outflow are putatively linked to asymmetric tonic contractions of the neck muscles in cervical dystonia (CD). At the population level, the interhemispheric asymmetry has been traditionally studied for the estimation of the spectral power in specified frequency bands. Broadband spectral features, however, were not taken into consideration. The contemporary analysis revealed that the aperiodic (1/f) broadband activity could be a neurophysiological marker of the excitation/inhibition ratio. During deep brain stimulation (DBS) surgery, we measured bilateral pallidal local field potentials (LFP) in nine CD patients, examining the effects of lateralized asymmetry on 1/f broadband activity. All patients showed a trend towards an asymmetric difference in the 1/f broadband activity. The ipsilateral 1/f slope was significantly higher in internal (GPi) segment of the globus pallidus that is on the contralateral side of the direction of the dystonia. We also found lateralized differences in the beta oscillations for GPi and in the alpha oscillations for GPe. Our findings emphasize the importance of mainstreaming broadband activity in the estimation of LFP spectral features together with periodic features and provide further evidence for the pallidal asymmetry in CD patients.

中文翻译：

宫颈肌张力障碍患者的上睑1 / f不对称

苍白球流出的侧向差异可能与颈肌张力障碍（CD）中颈部肌肉的不对称强直收缩有关。在人口一级，传统上已经研究了半球间不对称性，以估计特定频段的频谱功率。但是，宽带频谱特征并未考虑在内。当代分析表明，非周期性（1 / f）宽带活动可能是激发/抑制比的神经生理指标。在深部脑刺激（DBS）手术中，我们测量了9位CD患者的双侧苍白局部电场潜能（LFP），检查了偏侧不对称对1 / f宽带活动的影响。所有患者在1 / f宽带活动中均呈现出不对称差异的趋势。同侧1 / f斜率在苍白球的内部（GPi）节段中明显更高，该节段位于肌张力障碍方向的对侧。我们还发现GPi的beta振荡和GPe的alpha振荡存在侧向差异。我们的发现强调了将宽带活动纳入LFP频谱特征和周期性特征估计主流的重要性，并为CD患者的苍白不对称提供了进一步的证据。

更新日期：2020-04-01

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