The structure of the mouse incisor is characterized by its asymmetric accumulation of enamel matrix proteins on the labial side. The asymmetric structure originates from the patterning of the epithelial incisor placode through the interaction with dental mesenchymal cells. However, the molecular basis for the asymmetric patterning of the incisor germ is largely unknown.

中文翻译：

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Six1 是下切牙发育过程中信号中心形成和唇舌不对称所必需的。

小鼠门牙的结构特点是釉质基质蛋白在唇侧不对称堆积。不对称结构源于上皮切牙基板通过与牙间充质细胞的相互作用形成的图案。然而，门牙胚的不对称模式的分子基础在很大程度上是未知的。