Intestinal resident macrophages play a crucial role in homeostasis and have been implicated in numerous gastrointestinal diseases. While historically believed to be largely of hematopoietic origin, recent advances in fate‐mapping technology have unveiled the existence of long‐lived, self‐maintaining populations located in specific niches throughout the gut wall. Furthermore, the advent of single‐cell technology has enabled an unprecedented characterization of the functional specialization of tissue‐resident macrophages throughout the gastrointestinal tract.

中文翻译：

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肠道常驻巨噬细胞：肠道多任务细胞。

肠道常驻巨噬细胞在体内稳态中起着至关重要的作用，并与多种胃肠道疾病有关。尽管从历史上讲主要是造血起源的，但缘分映射技术的最新进展揭示了存在于整个肠壁特定壁long中的长寿，自我维持种群。此外，单细胞技术的出现使整个胃肠道中组织驻留巨噬细胞的功能专业化成为前所未有的特征。