The role of B cells in the immunopathogenesis of multiple sclerosis.,Immunology

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The role of B cells in the immunopathogenesis of multiple sclerosis.
Immunology ( IF 4.9 ) Pub Date : 2020-04-06 , DOI: 10.1111/imm.13198
Tohid Gharibi _{1,

2,

3,

4,

5} , Zohreh Babaloo _{1,

2} , Arezoo Hosseini _{1,

2,

3,

4} , Faroogh Marofi _{1,

2} , Abbas Ebrahimi-Kalan _{3,

4} , Saeed Jahandideh ₆ , Behzad Baradaran _{1,

2}

Affiliation

There is ongoing debate on how B cells contribute to the pathogenesis of multiple sclerosis (MS). The success of B‐cell targeting therapies in MS highlighted the role of B cells, particularly the antibody‐independent functions of these cells such as antigen presentation to T cells and modulation of the function of T cells and myeloid cells by secreting pathogenic and/or protective cytokines in the central nervous system. Here, we discuss the role of different antibody‐dependent and antibody‐independent functions of B cells in MS disease activity and progression proposing new therapeutic strategies for the optimization of B‐cell targeting treatments.

中文翻译：

B细胞在多发性硬化免疫发病机制中的作用。

关于 B 细胞如何促进多发性硬化症 (MS) 的发病机制一直存在争论。B 细胞靶向疗法在 MS 中的成功突出了 B 细胞的作用，特别是这些细胞的抗体非依赖性功能，例如向 T 细胞呈递抗原以及通过分泌致病性和/或中枢神经系统中的保护性细胞因子。在这里，我们讨论了 B 细胞的不同抗体依赖性和抗体非依赖性功能在 MS 疾病活动和进展中的作用，提出了优化 B 细胞靶向治疗的新治疗策略。

更新日期：2020-04-06

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