dbMTS: A comprehensive database of putative human microRNA target site SNVs and their functional predictions.,Human Mutation

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dbMTS: A comprehensive database of putative human microRNA target site SNVs and their functional predictions.
Human Mutation ( IF 3.3 ) Pub Date : 2020-04-06 , DOI: 10.1002/humu.24020
Chang Li ₁ , Chengcheng Mou ₂ , Michael D Swartz ₃ , Bing Yu ₄ , Yongsheng Bai ₅ , Yicheng Tu ₂ , Xiaoming Liu ₁

Affiliation

MicroRNAs (miRNA) are short noncoding RNAs that can repress the expression of protein-coding messenger RNAs (mRNAs) by binding to the 3'-untranslated region (UTR) of the target. Genetic mutations such as single nucleotide variants (SNVs) in the 3'-UTR of the mRNAs can disrupt miRNA regulation. In this study, we presented dbMTS, a database for miRNA target site (MTS) SNVs and their functional annotations. This database can help studies easily identify putative SNVs that affect miRNA targeting and facilitate the prioritization of their functional importance. dbMTS is freely available for academic use at http://database.liulab.science/dbMTS as a web service or a downloadable attached database of dbNSFP.

中文翻译：

dbMTS：假定的人类 microRNA 靶位点 SNV 及其功能预测的综合数据库。

MicroRNA (miRNA) 是短的非编码 RNA，可通过与靶标的 3' 非翻译区 (UTR) 结合来抑制蛋白质编码信使 RNA (mRNA) 的表达。基因突变，例如 mRNA 3'-UTR 中的单核苷酸变异 (SNV)，可以破坏 miRNA 的调控。在这项研究中，我们提出了 dbMTS，这是一个 miRNA 靶位点 (MTS) SNV 及其功能注释的数据库。该数据库可以帮助研究轻松识别影响 miRNA 靶向的假定 SNV，并促进对其功能重要性的优先排序。dbMTS 可在 http://database.liulab.science/dbMTS 作为网络服务或可下载的 dbNSFP 附加数据库免费用于学术用途。

更新日期：2020-04-06

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